Iran fired a new wave of missile attacks on Israel early Monday, triggering air raid sirens across the country as emergency services reported at least five killed and dozens more wounded in the fourth day of a conflict between the regional foes that showed no sign of slowing.

Israel says it has largely knocked out Iran's air defenses. In contrast, Israel still has strong air defenses in place, though some Iranian missiles are breaking through with lethal results.

Frank Ashley, the former interim Dean at the Bush School, was traveling to the Middle East as fighting was breaking out.

Iran has launched a new wave of missile attacks on Israel, triggering air raid sirens across the country as emergency services reported at least five killed and dozens more wounded in the fourth day of open warfare between the regional foes.

The State Department raised its travel advisory for Israel to Level 4, the highest level, amid airstrikes from Iran.