Madness picks, predictions, odds for Mount St. Mary's vs Duke first-round East Region game on Friday, March 21, 2025. Who wins?

Madness selection committee may have installed the Auburn Tigers as the No. 1 overall seed, but oddsmakers have the Duke Blue Devils favored to cut down the nets — even with Cooper Flagg’s injury status up in the air after hurting his ankle last week in the ACC tournament.

NCAA Tournament bracket has been announced and so the oddsmakers have returned to the drawing board to reset the national title odds that have been adjusted throughout the season in reaction to each week's results.