Boeing Co. Chief Executive Officer Kelly Ortberg finds himself in a familiar role — facing another crisis — this time a crash involving the company’s marquee 787 Dreamliner jet in India that killed more than 240 people.

A London-bound Air India plane carrying more than 240 people crashed shortly after takeoff Thursday. Authorities said there were no known survivors.

The S&P 500 ended higher on Thursday after a strong outlook from Oracle fueled optimism around artificial intelligence, offsetting worries about tension in the Middle East and a drop in Boeing shares.

U.S. stocks are drifting lower as momentum wanes from a big rally that had brought them to the brink of their record.

Related: Airport shuts down after Boeing 787 with 242 aboard crashes after takeoff. Part of the plane fell on top of the dining area of B.J. Medical College, killing at least five

The U.S. Treasury held a closely eyed $22 billion auction of 30-year bonds, and solid demand showed investors are still hungry for long-term government debt, despite policy uncertainty.

US stocks open down after Trump raised tariff tensions by promising unilateral tariff rates within two weeks. Boeing shares fall after a deadly crash.

U.S. equities were mixed and little changed at midday as a second inflation report this week came in lower than anticipated.